The house was worked in 1788 for John Blackburne, when this was in the farmland outside Liverpool. Blackburne initially originated from Warrington.
He was a rich salt purifier and a supporter of the slave exchange. In 1760 he had been Lord Mayor of Liverpool.
In 1844 the house was purchased from Blackburne by George Holt. Holt was a cotton specialist and trader, and an abolitionist.
He was additionally a supporter of ladies' rights, and on 5 August 1844 he opened the house as Blackburne House Girls' School with a Latin maxim which interprets as: "Conceived not for ourselves alone but rather for the entire of the world."
Blackburne House was the principal school for young ladies in Liverpool, and was sited straightforwardly inverse the Mechanic's Institute, a school for young men on the opposite side of Hope Street. Holt was the chief and leader of the school until he passed on in 1861, when the school was taken over by the Mechanic's Institute. The structure was reached out in 1874–76 by W. I. Artisan, who added a wing toward the north and a focal pinnacle.
In 1905 it went under the administration of Liverpool City Council, and proceeded as a school until it shut in 1986.